![]() ![]() There doesn’t seem to be a lot of English language information about it, though it seems like it became exclusive for the warrior class by the Edo period before being more or less outlawed in the Meiji period. This style was developed by and for samurai because it was used to keep their helmets in place. ![]() If the shaved/historical part is important there’s the chonmage, a Japanese hairstyle that also features a shaved hairline. There are however hairstyles that would be better suited for Val. It could also be argued that that part of history might have been forgotten, but it seems unlikely that something that was an important cultural feature for almost half a millennium would be forgotten so easily. It’s possible that his nationality has been retconned, but there’s no reason to do that and it’s pretty bad to imply that different cultures are so interchangeable that a character who’s even named after a Japanese martial art can just be changed to something else. The queue may therefore not be a great pick for a character in general, but Val is also supposed to be half-Japanese so he doesn’t even have any ties to it in the first place. ![]() not fully braided) was often seen as resistance against the Qing rule and the cutting of the queue was seen as an act of rebellion, which made it an important symbol during the eventual revolution.Ĭhinese workers abroad would also sometimes have their queues cut off as a way to degrade and humiliate them and they were often exaggerated in anti-Chinese propaganda. Not having a queue or not wearing it properly (eg. The queue hairstyle was mandate by law for Chinese men between 1644-1911 as part of an effort to assimilate the Han Chinese under the Manchurian lead Qing dynasty, and it became an important symbol for the dynasty. The queue is a traditional Manchurian hairstyle where the front part of the head is shaved while the back is kept long and generally braided, though the exact style of the haircut has varied depending on a lot of different factors. It’s a version of the Chinese queue, a hairstyle with a long and complex history. (Disclaimer: I’m not an expert on Chinese/Japaneses hairstyles, but I’ve tried to research as much as I could.) This is what Val’s hair looks like right now: ![]()
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![]() ![]() Prior data from KEYNOTE-042 trial at a median follow-up of 33 months (range, 25.6-41.9) showed pembrolizumab elicited significantly improved OS rates vs chemotherapy in the patients with a PD-L1 TPS of at least 50% (HR, 0.63 95% CI, 0.43- 0.94), at least 20% (HR, 0.66 95% CI, 0.47- 0.92), and at least 1% (HR, 0.67 95% CI, 0.50-0.89). “Pembrolizumab monotherapy remains a standard of care treatment for Chinese patients with previously untreated, locally advanced or metastatic NSCLC with PD-L1 TPS greater than or equal to 1 and without sensitizing EGFR or ALK alterations,” lead study author, Yi-Long Wu, MD, said in the poster presentation. Results showed that patients with PD-L1 tumor proportion score (TPS) of at least 50% achieved a 4-year OS rate of 23.4% and a median OS of 24.5 months (95% CI, 17.4-34.3) with pembrolizumab, compared with 13.6% and 13.8 months (95% CI, 10.1-18.3) with chemotherapy (HR, 0.66 95% CI, 0.45-0.95). As a matter of fact, this is has just been published by in The Lancet just about last week.Four-year overall survival results of the phase 3 KEYNOTE-042 trial (NCT02220894) and phase 3 China extension KEYNOTE-042 trial (NCT03850444) continue to show superiority of pembrolizumab (Keytruda) vs standard-of-care chemotherapy in Chinese patients with treatment-naïve advanced or metastatic non–small cell lung cancer (NSCLC) that expresses PD-L1 and does not harbor sensitizing EGFR or ALK mutations, according to data made available during the American Association for Cancer Research (AACR) 2022 Annual Meeting. So that pretty well gives you a capsule of what we have learned from this important randomised study. This group of patients then I think we can consider the single agent use as per 042. On the other hand, there are some patients who are physically not capable of receiving chemotherapy. So this group probably can be considered the utilisation of a KEYNOTE-189 regimen. So I wouldn’t promote to replace chemotherapy with the single agent pembrolizumab and especially there are data from KEYNOTE-189 demonstrating that the combination of chemo with pembrolizumab is actually superior to chemotherapy. Now, we come to the question that can we use single agent pembrolizumab in the 1-49% subgroup as a first line? In this study we actually did not show any superiority but then there is some advantage in terms of toxicity. So, in other words, whether you use 1% or 20% the benefit is mostly driven by the 50% subgroup. With this one we did not observe any overall survival benefit. But then, speaking of that, we also performed an exploratory analysis looking at the subgroup of 1-49%. ![]() At the same time we also find that there is an improvement in the over 20% cut-off and the over 1% cut-off. Now, the 50% subgroup of patients the advantage is actually similar with a very nice hazard ratio although the median is not as impressive as what we observed in 024. ![]() We were actually able to demonstrate an overall survival benefit when we looked at using a cut-off at 1%, 20% or 50%. In this randomised study we actually compared patients with over 1% expression, single agent pembrolizumab versus standard chemotherapy. Now, the importance of KEYNOTE-042 is, number one, it will support the efficacy of the patient over 50% and, second, it’s to say how about if we use 1% as a cut-off, are we going to observe an overall survival benefit? So those are the major differences about these two studies. KEYNOTE-042 is a similar design however we select the patients over 1% and using overall survival as the primary endpoint. So KEYNOTE-024 is actually selecting the patients of PD-L1 expression 50% or more and a primary endpoint of progression free survival. KEYNOTE-042 is the sister trial of KEYNOTE-024 – 24, 42. Professor Tony Mok – Chinese University of Hong Kong, Hong Kong Latest data from KEYNOTE 42: Pembrolizumab vs chemotherapy in treatment-naive patients (pts) with PD-L1 advanced NSCLC ![]() ![]() ![]() ![]() Some of the leading and trusted cold storage wallets include Trezor Model One, Ledger Nano S Plus, and Trezor Model T. In the realm of crypto, hardware or cold storage wallets are considered the most secure because they do not leave private keys online amid countless likely threats. It must be done right, however, as there are still risks involved, including the potential to lose your wallet, so make sure to keep a secure backup in a completely separate location. Not storing them yourself opens you up to counterparty risk, the risk of the custodian going bankrupt or losing your funds in other ways. Keeping cryptocurrency stored on personal, secure, air-gapped devices is generally accepted to be the safest way to hold crypto. Some of the best practices for keeping digital assets safe include: This means that a lot of the risks that threaten the security of crypto assets can be eliminated. Investors with proper security controls in place can trade safely and confidently. ![]() It is imperative to take precautions to guarantee the security of crypto assets, be it BTC, Ethereum (ETH), Ripple (XRP), meme coins like Dogecoin (DOGE) and Shiba Inu (SHIB), or NFTs. Moreover, cyber threats are unlikely to go down with the recent growth in generative AI. Not all crypto companies provide the level of security synonymous with banks. Investors, both institutional and retail, have the responsibility of ensuring the security of the digital assets they hold. 7 Best Practices for Ensuring Cryptocurrency Security These include holding their cryptocurrencies in a personal, secure wallet and simply avoiding connecting wallets to risky platforms. By leveraging certain security measures and processes and avoiding risky situations, they can make the most out of one of the fastest-growing industries globally without worrying about losing their hand-earned digital assets.Īlthough cybercriminals are always on the lookout for gaps and vulnerabilities that they can exploit, some simple actions are often much more important for the average investor. Cryptocurrency Thefts Are Almost Always PreventableĬryptocurrency investors are not defenseless against rampant security breaches. On the brighter side, the losses contracted by 55% in Q2 2023, compared to the first quarter of the same year, during which the industry hemorrhaged a staggering $462.3 million due to malicious attacks and deceptive schemes. The report disclosed that a mere $4.9 million was reclaimed out of the colossal $204.3 million lost to heists, frauds, and underhanded market manipulations in the second quarter of 2023, marking a significant dip compared to the $6.9 million recouped during the same period in 2022. Investors also lose funds in crypto scams and rug pulls. TechCrunch highlighted a significant drop in the number of losses due to security breaches on protocols, bridges, and exchanges, which had halved in Q2 2023 to $204 million. ![]() ![]() When it comes to writing your project management resume, your goal is to make the recruiter’s job as easy as possible. Project managers should also be aware of the difference between gold plating and scope creep, as sometimes the project team works past the point of diminishing returns. ![]() Highlight on your resume any projects where you wrote a detailed scope statement - and stuck to it. Project managers who can keep projects on track and successfully fight unnecessary scope creep are increasingly valuable to their organizations. Resources are tight, project complexity is on the rise, and speed of execution is more important than ever. Complex projects often mean larger teams to manage, more resources to coordinate, and more stakeholders to please. Resource managementĪs companies navigate increasingly complicated markets, their business strategies - and the projects to implement them - are becoming larger and more complex. The ability to confidently calculate an acceptable amount of risk and assess and manage threats (and opportunities) to your projects to achieve the best possible outcome will be a top skill for project managers. Risk assessment and managementĪs the global economy continues to recover, companies can't afford to take unnecessary risks or suffer project failure. With the fast pace of business and shifting market demands, project managers will need to understand business strategy to anticipate market changes and be ready when they hit. It's no longer enough to be responsive to change - you need to see it coming. Experience with Agile project management will become an expectation for project managers, not just a feather in your cap. And with the Internet of Things and wearables industries poised for massive growth, development teams, in particular, will have to quickly respond to a constant stream of data giving them new insights into what customers want. Agile experienceĪgile isn't the new kid on the block anymore it's the most popular project management methodology. Make sure these five essential skills are on your CV to land interviews at the leading companies on your list. Essential skills for your project manager resume Plus, discover project manager resume examples to compare yours to. Keep reading to find out what you need on your resume to score one of these opportunities and some important considerations based on what type of project manager you are. ![]() That means there will be as many as 505,000 new jobs created for project managers - one of which could belong to you. In addition to being one of the careers that are ideal for working from home, the Bureau of Labor Statistics predicts that, between now and 2024, management occupations, which include project management, will grow by 5%. ![]() If you're entering the job market this year - either for the first time or to make an exciting new career change - you may be wondering how to make your project manager resume stand out from the pack. ![]() ![]() How do you use them? Let us know in the comments. We’re always interested in finding new and different ways to use our original and unsweetened cashew milks. A Vanilla-Mint Mango Smoothie is the perfect place to start. How about trying these Mini Key Lime Pies? Cook your oatmeal with cashew milk instead of water for a more satisfying meal or pour a cup of cashew milk over cold cereal for a light and nutty boost in flavor. ![]() It steams and foams perfectly to make next-level lattes. Elmhurst cashew milk is Barista-Approved for exceptional coffee performance. Giant Cashew Tree Lost Ark Vista : ZafrostVideoGameGuide - Reddit d cashew questions. Pour it into a cup of hot coffee and watch as the coffee instantly transforms into a beautiful, mixed blend. Gd Cashew Cookies 200g Right Choice Super Mart Target WebMay 14. Elmhurst Cashew Milk is a coffee-enhancing wonder. Because of its pure, simple ingredients, the number one way people prefer this plant-based milk is drinking it by the glassful. The simplest way to enjoy cashew milk is on its own.
![]() Contained within one gram of protein and carbohydrate, is four calories, while one gram of fat contains 9 calories. Macronutrients – These are all the proteins, carbohydrates and fats contained within the food you eat over the course of a day. Fat after all is the body’s storage mechanism.Ģ. At the end of the day, if your input surpasses your overall output, the body will store the access calories as fat. Balancing the number of calories you consume in your food each day, is the most important aspect of any nutrition program or diet. Caloric intake and energy balance – Calories often get a bad rap from most dieters, most people think they need to avoid them like the plague without even understanding what they really are, thanks to food branding such as “low cal” or “diet friendly.” Calories are not a bad thing, but what they are actually is a measurement of heat, in fact they are the amount of energy needed to raise the temperature of one gram of water by one degree Celsius. I also won’t be pushing any specific diet, I’ll only be outlining rules that can be applied to any style of eating that you choose to follow.ġ. This is because that kind of information is specific to your current age, height, and weight. For the purposes of this post, I won’t be including specific targets for calories or macronutrients. In the case of diet and nutrition however, the $200 is a shift of focus onto macronutrients, or whatever the next level is for them. Once they can demonstrate to me that they can master this level, I will allow them to “pass Go” and collect their $200. I always get my clients to start by just focusing on nailing their calorie requirements for their intended goal and nothing else. Rather than juggling, caloric intake, macronutrients, nutrient timing, food composition and supplementation, I think a far better approach is to tackle each aspect of dieting one aspect at a time, based on their level of importance. I like to take a categorical approach to nutrition and break it down into much more digestible portions for my clients to handle. Nutrition is an extremely nuanced and complicated topic, that can be overwhelming for many, however it doesn’t have to be if you treat it like the “Go” rule in Monopoly. ![]() I see nutrition and dieting in a similar sense for my clients. At the beginning of every game, each player starts on this square, and every subsequent time they pass the “Go” square they can collect $200. In the game of monopoly “Go” is the first square on the board. ![]() ![]() Yes! You might have noticed that your cat sleeps frequently during the day, so you’d be forgiven for thinking that it means they’re super active at night. Their whiskers are extremely sensitive, so they can navigate their way around obstacles. They can find their way around with ease, while we stumble into things.Ĭats also possess incredible hearing, helping them locate their prey from the smallest sound. Consider how well adapted a cat’s eyes are to seeing in low-light conditions than our human eyes, meaning they can see far better than us in low-light conditions. Even if your cat doesn’t need to hunt their food anymore, those ingrained habits haven’t gone anywhere.Ī cat’s anatomy is far better adapted to night-time activities too. Therefore, it makes sense that many house cats’ natural rhythms coincide with when their prey is likely to be most active. Dusk and dawn are prime times for small prey animals to make the most of the safety that low-light conditions offer them in terms of not being seen while also having enough light so they can still see. Many species that cats would naturally predate, like rodents, feed from dusk until dawn. House cats still retain their hunting instincts from their wild ancestors, and this in turn, also influences the times of day that they’re most active. All cat breeds can trace their ancestry back to those original cats. It’s thought that the African Wildcat, or Felis silvestris lybica, was the first domesticated feline. ![]() Why Are House Cats More Active at Night, Dawn, & Dusk?Īs sweet and cuddly as our house cats sometimes seem, there’s no denying that they’re descended from wild animals. There are three main terms that can be used to describe the times of day that your cat is most active. Let’s find out more about exactly why our feline friends love to play in the evenings and into the night.īefore we dive into the details about your cat’s behavior, let’s take a quick look at the terminology. That means they may spend more time being active during the day and then sleep more at night. Some cats may alter their behavior to better fit in with the schedules of their human friends. As is the case for many behaviors that we see in our feline friends, it’s not a black-and-white situation. That means they’re mainly active at dawn and dusk. The short answer is that cats can display nocturnal behavior, but a more accurate definition for most cats is that they’re crepuscular. Another reason to wonder this is the sheer amount of time that most cats spend snoozing during the day! ![]() If your cat has been keeping you awake with their night-time antics, you might be wondering if cats are truly a nocturnal species. ![]() |
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